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KMID : 0381120100320040335
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Genes and Genomics
2010 Volume.32 No. 4 p.335 ~ p.344
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Organization and variation of the mitochondrial DNA control region in five Caprinae species
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An Jung-Hwa
Okumura Hideo
Lee Yun-Sun
Kim Kyung-Seok
Min Mi-Sook
Lee Hang
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Abstract
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The complete mitochondrial DNA (mtDNA) control region was analyzed from five species of the subfamily Caprinae; Naemorhedus caudatus, N. goral, Capra hircus, Capricornis swinhoei, and Capricornis crispus. Among these species, the control region ranged from 1,096 to 1,212 bp in length. Our results were compatible with the scheme of three domains (ETAS, Central, and CSB) within the control region. A + T < G + C was observed in all the domains. In the Korean gorals, of the 31 variable sites in the whole control region resulting in 15 haplotypes, 27 variable sites were in the ETAS domain. We found two to three tandem repeat in all five species examined in this study, three in N. caudatus and N. goral, two in Capra hircus and C. crispus, and one in C. swinhoei, respectively. All of these repeat units include two short sections of mirror symmetry (TACAT and ATGTA). Short mirror symmetries were well-resolved among five different species, although left domain has high substitution rates. By Kimura’s two parameter method, the genetic distances between the genera Naemorhedus and Capricornis were calculated and divergence time between Naemorhedus and Capricornis may be nearly 2Myr.
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KEYWORD
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Mitochondrial DNA, control region, D loop, Caprinae, Naemorhedus, Capricornis
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